Histamine receptors cerebellum

Hj receptors are widely distributed, especially in the cerebellum, thalamus, and hippocampus, and are located on neurons, astrocytes, and blood vessels. Hj receptors in brain vary widely from species to species. Since histamine does not easily cross... 

H2 receptors, which are coupled to adenylate cyclase were also found in the molecular layer of guinea pig cerebellum (Ruat et al., 1990). Hj receptors are autoreceptors involved in the inhibition of the release of histamine. A low level of H3 receptors were found to be homogeneously distributed throughout the rat cerebellar cortex (Arrang et al., 1987 Pollard et al., 1993). 

Histamine-stimulated adenylate cyclase activity is observed in only three of the regions so far examined in guinea-pig brain, namely hippocampus, cerebral cortex and striatum, and no effect has been observed in cerebellum, hypothalamus, thalamus, midbrain and pons-medulla [179]. Interestingly, this is exactly the distribution of H2-receptors deduced from binding studies with [3H]tiotidine [133]. 

Palacios J M, Wamsley J K. and Kuhar M J (1981c) GABA, benzodiazepine, and histamine-Hi receptors in the guinea pig cerebellum effects of kainic acid injections studied by autoradiographic methods. Brain Res 214, 155-162... 

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