Histamine-2 receptor upregulation

Smit MJ, Timmerman H, Alewijnse AE, Leurs R. From histamine H2 receptor regulation to reclassification of H2 antagonists inverse agonism as the basis for H2 receptor upregulation. Receptors Channels 1998 5 99-102. 

Smit, M. J., Leurs, R., Alewijnse, A. E. et al. (1996). Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc. Natl. Acad. Sci. USA 93, 6802-7. 

Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, Fung-Leung WP Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol 2004 142 161-171. 

The major receptors on the rat ECL cell and the different phases of ECL cell responses to gastrin and PACAP. Histamine release is virtually instantaneous, histidine decarboxylase is rapidly upregulated, and after some hours, ECL cell DNA synthesis is stimulated after gastrin administration. 

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