Histamine H i receptors

Histamine H.i receptors. 699. 727 Histamine H4 receptors. 699 Histamine receptna. 698-699 Histiocytes. 198 Histones, 833t 835... 

Trade names Adistan Alestol Astemina Astimal Astizol Hismanal Histeamen (Janssen) Pollon-Eze Simprox Stemiz Indications Urticaria, pruritus, allergic rhinitis Category Histamine H I receptor antagonist Half-life 20 Hours... 

Trade names Idulamine Idulian Lergocil Nalomet Optimine (Schering) Trinalin (Schering) Verben Zadine Indications Allergic rhinitis, urticaria Category Histamine H I receptor antagonist Half-life 9 hours... 

Category Histamine H I receptor antagonist Muscarinic antagonist Peripheral vasodilator Half-life 4 hours... 

Histamine H-l receptor antagonists compete with the binding of histamine to its Type I receptors which are predominantly located in cells of the vasculature, and... 

Doreulee N, Yanovsky Y, Flagmeyer I, Stevens DR, Haas HL, et al. 2001. Histamine H(3) receptors depress synaptic transmission in the corticostriatal pathway. Neuropharmacology 40 106-113. 

H-i-antihistamines block at histamine receptors as well as at adrenergic, cholinergic, and serotonin-binding receptors. 

I 7 Development of Anti-Ulcer H 2-Receptor Histamine Antagonists... 

Receptors. Histamine receptors are coupled to G-proteins. The H-i and H2 receptors are targets for substances with antagonistic actions. The H3 receptor is localized on nerve cells and may inhibit release of various transmitter substances, including histamine itself. 

Gastrointestinal. Patients taking continuous steroid, especially in combination with a nonsteroidal antiinflammatory drug (NSAID), have an excess incidence of peptic ulcer and haemorrhage of about 1-2%. It is plainly unreasonable to seek to protect all such patients by routine prophylactic antiulcer therapy, i.e. to treat 98 patients unnecessarily in order to help two. But such therapy (proton pump inhibitor, histamine H -receptor blocker, sucralfate) is appropriate when ulcer is particularly likely, e.g. a patient with rheumatoid arthritis taking an NSAID, or for patients with a history of peptic ulcer disease. There is increased incidence of pancreatitis. 

Bouthenet M-L, Ruat M, Sales N, Garbarg M, Schwartz JC (1988) A detailed mapping of histamine H -receptors in guinea-pig central nervous system established by autoradiography with [ I]iodobolpyr-amine. Neuroscience, 26, 553-600. 

Loratadine. 4 i8-Chloro-Sf6-dihydro-l lH bettzo [bjcyctoh epta[I, 2 bJpyridi n -11 -y f i den e) t-p f peri di n cca rb-oxylic acid ethyl ester ll-l/V- ethoxycarbonyl)-4-piperidyl-idene]-8-chlorO-6,l l -dihydrO-Sif-benzo cyclohepta-tl 2-6]pyridine Sch-29851 Clantin CLaritin Clarityne Lisino. C HjjClNjOji mol wt 3 2.89. C 69 01%, H 6,05%, Cl 9 26%, N 7-32%, O 8.36%. Nonsedating-type histamine H.-receptor antagonist. Prepn F. J. Vtllani, U.S. pat. 

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