Highlights of Modern Pharmaceutical Analysis

In addition to the number of activities already discussed, modern pharmaceutical analysis entails the following activities that are highlighted in this book  

Discovery of NCE and high-throughput screening Solid-state analysis of drug substances Degradation and impurity analysis of drug substances Preformulation analysis 

Our present state of knowledge requires that a large number of molecules be prepared and tested before a successful potential candidate can be identified. This makes the drug discovery process very complex and cumbersome. It is worthwhile to remember that an ideal potential drug candidate should 

The acquisition of fairly detailed physical information can allow for-mulators to prepare themselves to cope with unanticipated crises. For a well-understood system, it is theoretically possible to design an automated or semiautomated manufacturing scheme for which the processing variables 

A systematic approach to the physical characterization of pharmaceutical solids can be outlined and serve as a useful pedagogical device for the classification of the many available methods of physical characterization. Within this system, physical properties are classified as being associated with the molecular level (associated with individual molecules), the particulate level (pertaining to individual solid particles), or the bulk level (associated with an assembly of particulate species). 

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