High troughput screening

With the high troughput screening techniques available today pharmaceutical industries may screen for drug candidates, which are metabolized and/or are inhibitors of, e.g., CYP2D6. Such drugs are in the hands of... 

Bajorath J. Integration of virtual and high-troughput screening. 53. Nature Rev. Drug Disc. 2002 1 882-894. 

K. W. Recent advances in the solid phase synthesis of drug-like heterocyclic small molecules. Combinatorial Chem. High Troughput Screening 1999, 2, 191-210. 

Recently, Kiillertz and Fischer developed a new prolyl isomerase assay for high-troughput screening of up to 20,000 samples per day. This assay employs a disulfide-bonded cis peptide with internally quenched fluorescence. Cis/trans isomerization is initiated by rapid reductive ring opening and followed by the increase in fluorescence (G. Kiillertz and G. Fischer, unpublished). 

M. Banks, A. Cacace, J. O Connel, and J. Honston, High-Troughput Screening Evointion of Technology and Methods, in Drug Discovery Handbook, I ed. 

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