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High throughput screening chromatography

The use of direct UV spectrophotometry to measure sample concentrations in pharmaceutical research is uncommon, presumably due to the prevalence and attractiveness of high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS) methods. Consequently, most researchers are unfamiliar with the value of UV detection, mainly that it is generally much faster than other methods - a very important asset in high-throughput screening. [Pg.63]

Kim, MJ. et al. 2005. High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spec-trom. 19 2651. [Pg.245]

Muckenschnabel, R. Falchetto, L. M. Mayr, I. Filipuzzi SpeedScreen label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands. Anal. Biochem. 2004, 324, 241-249. [Pg.118]

Frontal affinity chromatography for the screening of mixtures. Comb Chem High Throughput Screen 2002, 5, 395-406. [Pg.245]

Niessen, W.M.A. Progress in liquid chromatography-mass spectrometry instrumentation and its impact on high-throughput screening. [Pg.283]

J. W. Hirschelman, W. H. et ah Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry application to resveratrol absorption and metabolism. Comb Chem High Throughput Screen 2003, 6, 757-767. [Pg.422]

Wilson, D. M., Wang, X., Walsh, E., and Rourick, R. A. (2001). High throughput log D determination using liquid chromatography-mass spectrometry. Comb. Chem. High Throughput Screen. 4 511-519. [Pg.83]

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High screen

High screening

High-Throughput Screening

High-throughput

Screen high-throughput

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