High throughput permeability

Wohnsland, F., Faller, B. High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. J. Med. 

Marino AM, Yarde M, Patel H, Chong S, Balimane PV (2005) Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds. Int J Pharm 297 235-241. 

Use of Caco-2 Cells in Drug Discovery 9.3.1 High-Throughput Permeability Screening... 

LC/MS/MS techniques with selective and sensitive detection methods make it possible to quantitatively analyze samples from Caco-2 cell and PAMPA buffer matrices. A high-throughput permeability screen with robust LC/MS technology can quickly generate information about structure-permeability relationships that are extremely valuable in the lead optimization phase for the selection of pre-clinical candidates with favorable oral bioavailability properties. 

Wohnsland, E. and Ealler, B. (2001) High-Throughput Permeability pH Profile and High-Throughput Alkane/Water log P with Artificial Membranes. Journal of Medicinal Chemistry, 44, 923—930. 

High-throughput, Permeable cell. Semi-intact cell... 

Wohnsland F, Faller B (2001) High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. J Med Chem 44 923-930 Youdim KA, Avdeef A, Abbott N (2003) In vitro transmonolayer permeability calculations often forgotten assumptions. DDT 8 997-1003... 

Wohnsland, E. Ealler, B. High-Throughput Permeability pH Prohle and High-Throughput Alkane/Water Log P With Artihcial Membranes," J. Med. Chem. 44, 923-930 (2001). 

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