High-performance liquid chromatography-microwave-induced plasma

J. M. Costa-Fernandez, F. Lunzer, R. Pereiro, N. Bordel and A. Sanz-Medel, Direct coupling of high-performance liquid chromatography to microwave-induced plasma atomic emission spectrometry via volatile-species generation and its application to mercury and arsenic speciation, J. Anal. At. Spectrom., 10, 1995, 1019-1025. 

Kollotzek, D., Oechsle, D., Kaiser, G., Tschopel, R and Tolg, G. (1984) Application of a mixed gas microwave induced plasma to an on-line element-specific detector for high performance liquid chromatography. Fresenius Z. Anal. Chem., 318, 485-489. 

Figure 6.1 Bar-graph of MeHg in CRM 580. The results correspond to six replicate determinations as performed by different laboratories using various methods. MEANS indicates the mean of laboratory means with 95% confidence interval. Abbreviations-. CVAAS, cold vapour atomic absorption spectrometry CVAFS, cold vapour atomic fluorescence spectrometry ECD, electron capture detection GC, gas chromatography HPLC, high-performance liquid chromatography ICPMS, inductively coupled plasma mass spectrometry MIP, microwave induced plasma atomic emission spectrometry QFAAS, quartz furnace atomic absorption spectrometry SFE, supercritical fluid extraction.

Online applications are by far the most important utilization of diode array spectrometry. High-performance liquid chromatography, supercritical fluid chromatography, capillary electrophoresis, and flow-injection techniques produce enhanced sensitivity and structure-related information due to coupling with diode-array-based detectors. Emission of the microwave-induced plasma generated in atomic emission detectors for capillary gas chromatography is also analyzed by means of UV-Vis diode array instruments. 

Application of a mixed-gas microwave induced plasma as an on-line element-specific detector in high-performance liquid chromatography, Fresenius Z. 

Kwon (. Y. and Moini M. (2001) Analysis of imderivatized amino add mixtures using high performance liquid chromatography dual osdllating nebulizer atmospheric pressure microwave-induced plasma ionization-mass spectrometry, J. Am. Soc. Mass Spectrom. 12 117-122. 

This chapter reviews and expands on the material presented by the authors at the 1987 Eastern Analytical Symposium. A short review of the work done in this area by other researchers will be presented for completeness. The primary focus will be on chromatographic sample introduction for plasma source MS. The use of ICP-MS for the detection of high performance liquid chromatography (HPLC) eluates will be discussed. Speciation of several As and Sn compounds found in the environment demonstrates the ability of ICP-MS to provide element specific detection at ultra-trace levels. In addition, gas chromatographic detection using He microwave-induced plasma mass spectrometry (MIP-MS) is shown to be a promising technique, particularly for the determination of halogenated species. 

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