1,2,5,6,9,10-Hexabromocy clododecane

Sellstrom U, A Kierkegaard, C de Witt, B Jansson (1998) Polybrominated diphenyl ethers and hexabromocy-clododecane in sediment and fish from a Swedish river. Environ Toxicol Chem Yl 1065-1072. 

A number of brominated compounds including hexabromocy-clododecane and a series of polybrominated diphenyl ethers have been found in samples of sediment and fish from a Swedish river (Sellstrom et al. 1998). 

Toxicology LD50 (oral, rat) > 5000 mg/kg, (dermal, rabbit) > 2000 mg/kg Uses Flame retardant for EPS, polyolefin, polyamide/polyimide wire insulation, adhesives, coatings, textiles synergist with hexabromocy-clododecane Features Reactive ManuUDistrib. Aldrich AmeriBrom Trade Names Great Lakes PHE-65 ... 

For more than half a century, brominated flame retardants (BFRs), often combined with synergists such as Sb203, have been used to reduce the risk of fire in clothing. S ome of them have been listed on Annex XVn (REACH) for restriction (see Table 1.2) or Annex XIV (REACH) for authorization (see Table 1.3). HBCD (hexabromocy-clododecane) and deca-BDE (decabromodiphenylelher) are submitted to notification requirements because they are listed as substances of very high concern (SVHCs). HBCD is on Annex XIV (a list of substances proposed for authorization) in REACH, the so-called sunset date for HBCD is August 21,2015. After this date only authorized uses of HBCD will be allowed in Europe. 

Harley KG, Marks AR, Chevrier J et al (2010) PBDE concentrations in women s serum and fecundability. Environ Health Perspect 118 699-704 Harrad S, de Wit CA, Abdallah MA-E et al (2010) Indoor contamination with hexabromocy-clododecanes, polybrominated diphenyls ethers, and perfluoroalkyl compounds An important exposure pathway for people Environ Sci Technol 44 3221-3231 Harrad SJ, Ibarra C, Diamond ML et al (2008) Polybrominated diphenyl ethers in domestic indoor dust from Canada, New Zealand, United Kingdom and United States. Environ Int 34 232-238... 

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