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Heterotrimeric G proteins

Lambright, D.G., et al. Structural determinants for activation of the a-subunit of heterotrimeric G protein. Nature 369 621-628, 1994. [Pg.281]

Fluoride forms a tetrahedral ion with aluminum, AIF4, which forms a complex with the GDP -a (3 y form of heterotrimeric G-proteins. In the case of Gs, the complex AIF4 -GDP -a s(3 y behaves much as GTP or the more stable GTP derivatives, GTPy S or GPP(NH)P,... [Pg.52]

CC, and one CX3C and XC chemokine receptors have been cloned so far [2]. Receptor binding initiates a cascade of intracellular events mediated by the receptor-associated heterotrimeric G-proteins. These G-protein subunits trigger various effector enzymes that lead to the activation not only of chemotaxis but also to a wide range of fimctions in different leukocytes such as an increase in the respiratory burst, degranulation, phagocytosis, and lipid mediator synthesis. [Pg.352]

Heterotrimeric G-Proteins Adenylyl Cyclases Bone Metabolism... [Pg.508]

Heterotrimeric G-proteins Table Appendix Receptor Proteins... [Pg.515]

S-acylated proteins include many GTP-binding regulatory proteins (G proteins), including most a subunits of heterotrimeric G-proteins and also many members of the Ras superfamily of monomeric G proteins, a number of G protein-coupled receptors, several nonreceptor tyrosine kinases, and a number of other signaling molecules, -acylation is posttranslational and reversible, a property that allows the cell to control... [Pg.691]

Muscarinic acetylcholine receptors (mAChRs) form a class of cell surface receptors that are activated upon binding of the neurotransmitter, acetylcholine. Structurally and functionally, mAChRs are prototypical members of the superfamily of G protein-coupled receptors. Following acetylcholine binding, the activated mAChRs interact with distinct classes of heterotrimeric G proteins resulting in the activation or inhibition of distinct downstream signaling cascades. [Pg.794]

Transmembrane Signaling Heterotrimeric G-Proteins Nociception Analgesics... [Pg.835]

The 3 isozymes are activated by G protein-coupled receptors through two different mechanisms [2]. The first involves activated a-subunits of the Gq family of heterotrimeric G proteins (Gq, Gn, Gi4, G15/16). These subunits activate the (31, (33 and (34 PLC isozymes through direct interaction with a sequence in the C terminus. The domain on the Gqa-subunit that interacts with the (3 isozymes is located on a surface a-helix that is adjacent to the Switch III region, which undergoes a marked conformational change during activation. The second mechanism of G protein activation of PLC 3 isozymes involves (3y-subunits released from Gi/0 G proteins by their pertussis toxin-sensitive activation by certain receptors. The 3y-subunits activate the 32 and 33 PLC isozymes by interacting with a sequence between the conserved X and Y domains. [Pg.969]

Heparin Sulfate Proteoglycans Hepatic Lipase Hepatitis Hepatitis C Heptahelical Domain Heptahelical Receptors HERG-channels Heterologous Desensitization Heterologous Expression System Heterotrimeric G-Proteins Hidden Markov Model High-density Lipoprotein (HDL)... [Pg.1493]

Weiner CP, Mason CW, Buhimschi C, Hall G, Swaan PW, Buhimschi I. Changes in uterine GTPase activity are not consistent with changes in expression of Ga subunits of heterotrimeric G-proteins A potential mechanism for myometrial quiescence. Society of Gynecological Investigation. Los Angeles, CA, 2005. [Pg.161]

Fig. 12. Tentative model of the signal transduction chain that links the perception of pectic fragments to defense responses in carrot cells. Abbreviations apy, heterotrimeric G protein CaM, calmodulin 4CL, 4-coumarate-CoA ligase CTX, cholera toxin FC, fusicoccine GDP-P-S and GTP-y-S, guanosine 5 -0-(2-thiodiphosphate) and guanosine 5 -0-(3-thiotriphosphate) IP3, 1,4,5-inositol trisphosphate PAL, phenylalanine ammonia-lyase PLC, phospholipase C PR, pathogenesis related PTX, pertussis toxin Rc, receptor SP, staurosporine. Activation and inhibition are symbolized by + and -respectively. Fig. 12. Tentative model of the signal transduction chain that links the perception of pectic fragments to defense responses in carrot cells. Abbreviations apy, heterotrimeric G protein CaM, calmodulin 4CL, 4-coumarate-CoA ligase CTX, cholera toxin FC, fusicoccine GDP-P-S and GTP-y-S, guanosine 5 -0-(2-thiodiphosphate) and guanosine 5 -0-(3-thiotriphosphate) IP3, 1,4,5-inositol trisphosphate PAL, phenylalanine ammonia-lyase PLC, phospholipase C PR, pathogenesis related PTX, pertussis toxin Rc, receptor SP, staurosporine. Activation and inhibition are symbolized by + and -respectively.
It is appreciated that certain ion channels appear to be directly regulated by various G-proteins [126]. The cardiac and skeletal muscle L channels appear to be capable of being directly activated by Gs (the heterotrimeric G-protein that stimulates adenylate cyclase), in a manner that appears to be independent of second messenger... [Pg.331]


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Activation of Heterotrimeric G Proteins

Classification of the Heterotrimeric G-Proteins

Heterotrimeric proteins

Signal transduction pathways through heterotrimeric G proteins transmission of hormonal and sensory signals

The Functional Cycle of Heterotrimeric G-Proteins

The Heterotrimeric G-Proteins

Toxins as Tools in Characterization of Heterotrimeric G-proteins

Toxins as Tools in the Characterization of Heterotrimeric G Proteins

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