Heterocycles palladium-activated carbon nucleophiles

Intramolecular oxo- or aminopaUadation provides an eflFicient tool for the preparation of various heterocyclic derivatives in recent years. In 2010, Alvarez et al. reported an effcient palladium-catalyzed tandem intramolecular oxopalladation/oxidative Heck coupling reaction toward benzofuians 196 [77] (Scheme 6.54). Nucleophilic attack of the oxygen to the activated carbon-carbon triple bond furnishes vinylpal-ladium intermediate 197, followed by alkene insertion into the C-Pd bond to afford alkylpalladium intermediate 198. The final product was generated via P-hydride elimination of intermediate 198. 

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