Herpes simplex virus infection cidofovir

Cidofovir is an acyclic nucleotide analogue of the monophosphate of cytosine. When phosphorylated by host cellular enzymes, the active compound cidofovir diphosphate has broad activity against the herpes viruses, including CMV, herpes simplex viruses 1 and 2, varicella zoster virus and Epstein-Barr virus. Cidofovir is used primarily in treatment of CMV retinitis in patients who have failed treatment with ganciclovir or foscamet and in acyclovir-resistant herpes simplex infections. 

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