Herbicide/safener interaction

Safener Interactions with the Herbicide Target Site... 

It is usually part of the investigations on the mechanism(s) of safener action to look for possible safener interactions with the herbicide partner at the process of herbicide uptake into the crop. Looking through the relevant literature gives a complex picture. This can also be seen in a review of Davies and Caseley [2], who present an exhaustive compilation of safener effects on herbicide uptake for relevant herbicide/safener combinations developed up to that time. Only in 20% of the cases was the uptake of the herbicide reduced in combination with the... 

In other studies, it was shown that pretreatment with the safeners dichlormid and naphthalic anhydride (NA) increased significantly the activity of ALS in treated corn seedlings. The in vitro inhibition of ALS by chlorsulfuron, however, was either unaltered or increased by pretreatment with the safeners. Rubin and Casida proposed that the dichlormid-induced elevation in ALS activity in vivo is sufficient to offer partial protection to corn against injury from the herbicide chlorsulfuron. In similar studies on the interactions between safeners and imidazolinone herbicides, Barrett failed to detect any measurable effects of the safeners NA, dichlormid, oxabetrinil, and flurazole on extractable ALS activity in shoots or roots of corn and sorghum seedlings. 

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