Heparin proteoglycans

Fig. 2.—Schematic Representation of the Heparin Proteoglycan. [The polysaccharide chains, bound to the polypeptide matrix through a linkage region," are cleaved by tissue endoglycosidases (arrows) after the transformations illustrated in Scheme 1.]...

Oligosaccharide Fragments Isolated from the Carbohydrate-Protein Linkage-Region of Heparan Sulfate and Heparin Proteoglycans... 

Heparin has the same general stmcture as heparan sulfate. Heparin proteoglycan is found exclusively in granules of mast cells [4]. Heparin itself, which is obtained by degradation of the native proteoglycan, is a potent anticoagulant. Chondroitin 4,6-disulfate is also stored in mast cell granules. 

Schwartz, L.B., Riedel, C., Caulfield, J.P., Wasserman, S.I. and Austen, K.F. (1981b). Cell association of complexes of chymase, heparin proteoglycan and protein after degranulation of rat mast cells. J. Immunol. 126, 2071-2078. 

Stevens, R.L., Fox, C.C., Lichtenstein, L.M. and Austen, K.F. (1988b). Identification of chondroitin sulfate E proteoglycans and heparin proteoglycans in the secretory granules of human lung mast cells. Proc. Natl. Acad. Sci. USA 85, 2284-2287. 

Homer, A.A. Yoimg, E. (1982) Asymmetric Distribution of Sites with High Affinity for Antithrombin III in Rat Skin Heparin Proteoglycans , Journal of Biological Chemistry, 257, 8749-54... 

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