Heparin lock

Into an intermittent venous access device called a heparin lock (a small IV catheter in the patient s vein connected to a small fluid reservoir with a rubber cap through which the needle is inserted to administer the drug)... 

Clearing intermittent infusion (heparin lock) sets To prevent clot formation in a heparin lock set, inject dilute heparin solution (heparin lock flush solution, USP or a 10 to 100 units/mL heparin solution) via the injection hub in a quantity sufficient to fill the entire set to the needle tip. Replace this solution each time the heparin lock is... 

Use heparin lock-flush solution with caution in infants with disease states in which there is an increased danger of hemorrhage. The use of the 100 unit/mL concentration is not advised because of bleeding risk, especially in low-birth-weight infants. 

Saxena AK, Panhotra BR, Naguib M. Sudden irreversible sensory-neural hearing loss in a patient with diabetes receiving amikacin as an antibiotic-heparin lock. Pharmacotherapy... 

Wood M, Shand DG, Wood AT. Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for sampling. CUn Pharmacol Ther 1979 25(l) 103-7. 

Diminished cardiac activity and increased renal activity has been observed when a heparinized catheter was used for in vivo red cell labeling with pyrophosphate. This was interpreted as formation of a Tc-heparin complex that localizes avidly in the kidneys (Hegge et al. 1978). Injection of Sn-pyrophosphate and " Tc-pertechnetate through a heparin lock should be avoided. 

Heparin Lock Flush, Hep-Lock, Heplock U/P, Liquaemin sodium)... 

Thrombosis/embolism, diagnosis and treatment of disseminated intravascular coagulation (DIG), prophylaxis of deep vein thrombosis (DVT), clotting prevention Gearing intermittent infusion lines (heparin lock) to prevent clot formation at site... 

Heparin Lock Flush (Abbott) Lipo-Hepin (Riker) Liquaemin Sodium (Organon) Liquemin (Roche) ... 

Published guidelines on the management of catheter-related infections are in favor of the use of ALT for the treatment of catheter-related infections [24]. The in vitro stability of antibiotic-heparin combinations in CVCs was studied by Vercaigne et al. [25]. While ciprofloxacin produced immediate precipitation with heparin, cefazolin, vancomycin and ceftazidime at 10 mg/ml and gentamycin at 5 mg/ml were successfully incubated with heparin (5,000 U/ml) for 72 h in the central venous catheter lumen. Although free antibiotic in CVC solution was reduced, the final concentration was still sufficient for an effective antibiotic-heparin lock [25]. Good evidence is available to support ALT in the prevention of catheter-related bacteremia in patients on hemodialysis [26,27]. However, others have reported that the use of ALT may be limited due to antibiotic toxicity and the appearance of antibiotic-resistant microbial isolates [28, 29]. 

Vercaigne LM, Sitar DS, Penner SB, Bernstein K, Wang GQ, Burczynski FJ Antibiotic-heparin lock in vitro antibiotic stability combined with heparin in a central venous catheter. Pharmacotherapy 2000 20 394-399. 

Zhao Y, Li Z, Zhang L, Yang J, Yang Y, Tang Y, Fu P Citrate versus heparin lock for hemodialysis catheters a systematic review and metaanalysis of randomized controlled trials. Am J Kidney Dis 2014 63 479-490. 

---