Heparin gel-cream

Dissolve heparin sodium in water, add Lutrol E 400 and liquid paraffin. 

Stir and cool to 6°C. Add Lutrol F 127 slowly, and stir until it is dissolved. 

Heat to room temperature when the air bubbles escape. 

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Similar to Voltaren" Emulgel, oily droplets of an eutectic mixture of lidocaine and prilocaine are dispersed in a hydrogel to provide local anesthesia to the skin for injections and siugical treatment (Emla cream). A further possibility is the dermal administration of a liposome dispersion as a spray (Heparin PUR ratiopharm Spriih-gel "). After administration, water and isopropylic alcohol evaporate partially resulting in an increase of concentration and in a transition from the initial liposome dispersion into a lamellar liquid crystal [32]. The therapeutic effect appears to be influenced favorably by the presence of lecithins rather than by the degree of liposome dispersion. 

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