Nephritis Henoch-SchOnlein

The ACE gene encodes two isozymes (somatic ACE isozyme and germinal ACE isozyme). ACE is a membrane-bound enzyme on the surface of vascular endothelial cells that also circulates in plasma and shows great individual variability determined by an I/D polymorphism in intron 16 of the ACE gene (ACE-I/D polymorphism). More than 160 ACE polymorphisms have been reported, 34 of which are located in coding regions, and 18 are missense mutations (606). ACE-related polymorphic variants have been associated with hypertension, atherosclerosis, stroke, left ventricular hypertrophy, chronic renal failure in IgA nephropathy, Henoch-Schonlein purpura nephritis, mechanical efficiency of skeletal muscle, intracranial aneurysms, susceptibility to myocardial infarction, diabetic nephropathy, AD, and longevity (12,606,607). 

Bergstein J, Leiser J, Andreolli SP. Response of crescentic Henoch-Schonlein purpura nephritis to corticosteroid and azathioprine therapy. Clin Nephrol 1998 49 9-14. 

Acute renal insufficiency has been observed in a patient with Henoch-Schonlein syndrome (50). Another case presented as interstitial nephritis with acute renal insufficiency (51). 

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