Hematopoietic toxins

Benzene, a component of motor fuel that is also widely used as an industrial solvent and as a starting material in organic synthesis, is a hematopoietic toxin. Chronic exposure to benzene vapors leads to pancytopenia, that is, decreased production of all types of blood cells (erythrocytes, leukocytes, and platelets). The long-term effect of benzene exposure is acute leukemia. 

HEMATOPOIETIC TOXINS Toxic to the blood and blood-forming organs. 

Shinozuka, J. et al. T-2 toxin-induced apoptosis in hematopoietic tissues of mice. Toxicol. Pathol. 26, 674, 1998. 

The hematopoietic and nervous systems are frequently severely affected by industrial toxins. 

Shinozuka, J., Suzuki, M., Noguchi, N., Sugimoto, T., Uetsuka, K., Nakayama, H. et al. (1998). T-2 toxin-induced apoptosis in hematopoietic tissues of mice. Toxicol. Pathol. 26 674-81. 

Based on the case reports, case studies, and epidemiological studies, the sub-classification to cell types is indicated from a medical point of view to treat various hematopoietic diseases and cancers with the various appropriate treatments per each type of cell injured, however the data from the experimental data and clinical analysis of benzene cases clearly show that benzene causes damage to the stem cell and therefore it is a pluripotent toxin, causing a wide range of lymphohematopoietic malignancies. 

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