Helio trine

I = l-Methoxymethyl-l,2-dehydropyrrolizidine, II = its 7p-hydroxy derivative, III = helio-trine, IV = monocrotaline, V = senecionine... 

The relative susceptibilities of male and female rats to lasiocarpine and helio-trine have been studied. Male rats proved to be more resistant than females to fatal hepatic lesions following repeated intraperitoneal injection of lasiocarpine, but the reverse was true when heliotrine was injected. Renal lipomatous tumours have also been shown to be produced in rats treated with Heliotropium supinum, Amsinckia intermedia, or retrorsine. ... 

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