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Heck, Nobel prize

Some of the most exciting reactions in organic chemistry make use of transition metals, and in recent years three Nobel prizes have been awarded for work in this area. How about this example It is a Heck reaction, which allows nucleophilic addition to an unactivated alkene. Just a catalytic amount of palladium is needed to make the reaction go the most useful organometallic reactions are those in which the metal acts catalytically. [Pg.1069]

The cross-coupling reactions developed over the past 50 years have now been recognized by Nobel prizes to Heck, Suzuki, and Negishi. The relevance of these reactions in synthesis is obvious by the enormous number of publications dealing with the applications for the formation of sp carbon to sp carbon bond formation. Perhaps for this reason, only a few examples will be presented here, as the cycloheptanoid skeleton is basically made up of sp carbon atoms. Certainly, the inherent creativity of the synthetic organic chemist will change this situation very soon. [Pg.439]

Heck, R. F. NoUey, J. P., Jr. J. Am. Chem. Soc. 1968, 90, 5518-5526. Richard Heck discovered the Heck reaction when he was Hercules Corp. Heck won Nobel Prize in 2010 along with Akira Suzuki and Ei-ichi Negishi for palladium-catalyzed cross couplings in organic synthesis . [Pg.306]

Robert F. Heck shared the 2010 Nobel Prize in Chemistry with Ei-iohi Negishi and Akira Suzuki for development of palladium-catalyzed cross coupling reactions. [Pg.1243]

Among these reactions, three were recognized with a Nobel Prize in Chemistry in 2010. The Nobel Prize was awarded on the basis of practical use in the industrial sector. Heck reactions were used for the synthesis of more than 100 kinds of natural products and physiologically active substances, Negishi reactions were used for the synthesis of pumiUotoxins A (PTXs) and hennoxazole A, and Suzuki-Miyaura reactions were used for the syuthesis of dynemicin A and dragmacidin F [ 100,101]. [Pg.159]

In 2010, Richard Heck, Ei-ichi Negishi, and Akira Suzuki shared the Nobel Prize in Chemistry for their work on C—C coupling reactions. [Pg.1065]

Scheme 7.16. Some examples of the Suzuki reaction. The process permits creation of carbon-carbon bonds by coupling of alkyl, alkenyl, and aryl halides (I > Br Cl) with organoboron compounds. Akira Suzuki, Ei-ichi Negishi and Richard Heck shared the Chemistry Nobel Prize in 2010. Scheme 7.16. Some examples of the Suzuki reaction. The process permits creation of carbon-carbon bonds by coupling of alkyl, alkenyl, and aryl halides (I > Br Cl) with organoboron compounds. Akira Suzuki, Ei-ichi Negishi and Richard Heck shared the Chemistry Nobel Prize in 2010.
In 1968, Heck reported stoichiometric reactions of alkenes with [ ArFd Cl] (generated in situ by reacting ArHgCl with Li PdCy leading to ArCH=CHR [4a]. Mizoroki reported in 1971 the first catalytic reactions between Phi and alkenes, in the presence of catalytic PdCI and KOAc as base [5a]. In 1972, the catalytic reactions were unproved by Heck upon using Pd(OAc)2 and /iBu N as a base [4b], In 1973, Mizoroki in a last contribution extended the scope of its preUminaiy work to PhBr with the reactivity order PhI PhBr [5b]. In 1974, Heck developed the use of PPII3 in association with Pd(OAc)2 to allow reactions of ArBr at 100-135°C [4c]. In 1978, Heck introduced the tri-o-tolylphosphine P(o-Tol)j in association with Pd(OAc)2 that let the reaction with ArBr proceed at lower temperatures (75°C) [4d]. The foundation for what is called the Mizoroki-Heck reaction was established. Heck received the Nobel Prize in 2010. [Pg.514]

As a final comment, although restricted in its essence to palladium chemistry - but which is nonetheless at the heart of modern cross-coupling arylation reactions - we quote from Astruc [12i], in conclusion, the field of palladium-catalyzed cross-coupling reactions for their work in which Heck, Negishi, and Suzuki were awarded the 2010 Nobel Prize in chemistry is extremely rich and productive and will continue to grow with major synthetic applications and green implications in the future. ... [Pg.84]

The 2010 Nobel Prize in Chemistry was awarded to Richard F. Heck (University of Delaware), Ei-ichi Negishi (Purdue University), and Akira Suzuki (Hokkaido University) for their work on paiiadium-cataiyzed cross-coupiing reactions. Eariy and important contributions were made by John Stille (Colorado State University) before his untimely death in a 1989 plane crash. [Pg.595]

The Mizoroki-Heck reaction is one of the most versatile methods for generating new C-C bonds. Using palladium-based complexes, the reaction couples an unsaturated center, often a vinyl or aryl group, to one end of an alkene C=C bond (Scheme 4.62) [209]. Both inter- and intramolecular examples are known. This methodology is more often called the Heck reaction, and has recently been recognized with the 2010 Nobel Prize in chemistry. [Pg.151]

Professor Richard F. Heck (b. 1931), University of Delaware, Nobel Prize 2010 (chemistry). [Pg.561]


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