HEAT repeats

TOR Signalling. Figure 2 Dimeric structure of mTORCI and mTORC2. mTORCI contains mTOR, raptor and mLST8. Raptor binds the HEAT repeats of mTOR, mLST8 binds the kinase domain of mTOR. mTORC2 contains mTOR, rictor, Sini and mLST8. Rictor and Sini cooperatively bind the HEAT repeats of mTOR. 

No harm is done when the electrolyte is allowed to solidify in the generator but when it is again melted, the burners should be allowed to melt the top part of the solid before the bottom is heated. Repeated violation of this precaution might rupture the apparatus, because the density of the solid is greater than that of the liquid. A circular gas burner which directs flames inwardly may be adjusted to heat the cell in the desired manner. No heating is necessary while electrolysis is in progress, unless a small current is used. 

Andrade MA, Bork P (1995) HEAT repeats in the Huntington s disease protein. Nat Genet 11 115—116. 

Grinthal A, Adamovic 1, Weiner B et al (2010) PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis. Proc Natl Acad Sd USA 107 2467-2472... 

IV. HEAT Repeats within eIF4G Direct Assembly of Translation Machinery. 283... 

The structure of the middle domain unexpectedly revealed that the eIF4Gs are members of the HEAT repeat family of proteins [named for... 

Fig. 6. Struct ure of the middle domain ofeIF4G. Ribbon drawing oftbe conserved central region of human eIF4GII viewed along the axes of the a-helices. HEAT repeats are labeled 1-5 and individual a-helices within each repeat are labeled a and b. The convex and concave surfaces are formed by a and b helices, respectively. The intra-and interrepeat loops are located on the background and foreground of the figure, respectively. [Adapted from Marcotrigiano et al. (2001).]...

Smith L, Van Hateren N, Siggers P Larder R, Willan J, Walsh J, Arkell A, Greenfield A (2003) Candidate testis determining gene. Maestro (Mro), encodes a novel HEAT repeat protein. Dev Dyn. 227,600-607. 

Add 15 ml dry acetone, swirl to dissolve and evaporate to a low volume on the steam bath (caution flammable vapour). Complete evaporation under a jet of air without heating. Repeat twice more. 

Evaporate the butan-l-ol extracts almost to dryness. Add 5 ml diethyl ether and evaporate to dryness under an air jet without heating. Repeat. 

Wodl] x=0.8 Lattice constant depending on temperature, see Fig. 58 (transition orthorhombic-hexagonal structure) (X, powder. Appropriate mixture of 833003, V2O5 and Xi02 heated repeatedly in a H2S-stream at 650---750 °C). 

Kemper WM, Berry KW, Merrick WC (1976) Purification and properties of rabbit reticulocyte protein synthesis initiation factors M2Balpha and M2Bbeta. J Biol Chem 251 5551-5557 Kim SC, Sprung R, Chen Y et al (2006a) Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell 23 607-618 Kim YS, Kang KR, Wolff EC d al (2006b) Deoxyhypusine hydroxylase is a Fe(ll)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected]. J Biol Chem 281 13217—13225... 

Park JH, Aravind L, Wolff EC et al (2006) Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase a HEAT-repeat-containing metalloenzyme. Proc Natl Acad Sci USA 103 51-56... 

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