Haslea ostrearia

Allard W. G., Belt S. T., Masse G., Naumann R., Robert J.-M., and Rowland S. J. (2001) Tetra-unsaturated sesterterpenoids (Haslenes) from Haslea ostrearia and related species. Phytochemistry 56, 795-800. 

The blue-green filamentous algae Spirulina platensis also inhibited HIV-1 replication in human T-cell lines, peripheral mononuclear blood cells and Langerhans cells [16]. The extract inactivated HIV-1 infectivity directly when preincubated with the virus before addition to human T-cell lines. These data indicate that aqueous Spirulina platensis extract contains antiretroviral activity that may be of potential clinical interest. Antiviral activities were also reported from the water-soluble fraction of the marine diatom Haslea ostrearia, which delayed HIV-1-induced sincytia formation on MT-4 cells [17]. 

A marine Pseudomonas species WAK-1 produced extracellular glycosaminoglycan and showed anti-HSV-1 activity in RPMI 8226 cells [105], while the water-soluble fraction of the marine diatom Haslea ostrearia delayed HSV-1-induced syncitia formation [17]. A novel acid PS, nostoflan, was isolated from the cyanobacterium Nostoc jlagelliforme, which had a broad antiviral spectrum against enveloped viruses, including HSV-1 and HSV-2, whose cellular receptors are carbohydrates [106]. Two new... 

Johns L, Belt S, Lewis CA, Rowland S, Masse G, Robert JM, Konig WA. Configurations of polyunsaturated sesterterpe-noids from the diatom, Haslea ostrearia. Phytochem. 2000 53 607-611. 

Figure 9.7 Examples of sesterterpenes isolated from Haslea ostrearia (Wraige et al., 1999 Belt et al., 2006, 2007).

Belt, S.T, Cooke, D.A., Robert, J.M., and Rowland, S. (1996) Stmctural characterisation of widespread polyunsaturated isoprenoid biomarkers A C25 triene, tetraene and pentaene from the diatom Haslea ostrearia Simonsen. Tetrahedron Lett., 37, 4755 758. 

Belt, S,T, Masse, G., Rowland, S.J., and Rohmer, M. (2006) Highly branched isoprenoid alcohols and epoxides in the diatom Haslea ostrearia Simonsen. Org. Geochem., 37,133-145. 

Johns, L., Belt, S., Lewis, C.A., Rowland, S., Masse, G., Robert, J.M., and Konig, W.A. (2000) Configurations of polyunsaturated sesterterpenoids from the diatom, Haslea ostrearia. Phytochemistry, 53, 607-611. 

Pouvreau, J.-B., Moranais, M., Mass, G., Rosa, P., Robert, J.M., Fleurence, J., and Pondaven, P. (2006) Purification of the blue-green pigment marennine from the marine tychopelagic diatom Haslea ostrearia (Gaillon/Bory) Simonsen./. Appl. Phycol, 18, 769-781. 

Robert, J-.M., Moranqais, M., Pradier, E., Mouget, J.-L., and Tremblin, G. (2002) Extraction and qualitative analysis of the blue-green pigment marennine synthesized by the diatom Haslea ostrearia. J. Appl Phycol, 14, 299-305. 

Rossignol, N., Jaouen, P., Robert, J.-M., and Quemeneiu, F. (2000) Production of exocellular pigment by the marine diatom Haslea ostrearia Simonsen in a photobioreactor equipped with immersed ultrafiltration membranes. Bioresour. Technol., 73,197-200. 

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