Scale hard shell capsules

Practical Considerations in the Scale-Up of Powder-Filled Hard Shell Capsule Formulations... 

Powders as such or encapsulated into hard shells (capsules) are alternatives to tablets. They are needed for example to obtain appropriately sized dosage units for children. Both powders and capsules are relatively easy to prepare (Ml a small scale. Often, pharmacists use commercially available medicines as a starting point to prepare the dosage forms, rather than starting ab initio from the active pharmaceutical substance with selected excipients. Pulverised tablets (if possible) can be used for the preparation of capsules with a lower dose than the one present in tablets intended for adults. Alternatively, the contents of capsules can be diluted to provide the dose required by the patient. 

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