Haplophyllum hispanicum tuberculatin from

From the methanol extract of Haplophyllum hispanicum (Rutaceae) two topical anti-inflammatory aryl naphthalide lignans were isolated and identified as diphyllin acetyl apioside and tuberculatin [284], The methanol extract was only active against the acute TPA-induced ear edema, whereas it was not active against the chronic inflammation induced by TPA or oxazolone-induced contact-delayed hypersensitivity in mouse ears. Diphyllin acetyl apioside was the most active of the isolated compounds on the acute TPA, with an ID50 of 0.27 pmol/ear, whereas tuberculatin gave an ID50 of 1.23 pmol/ear. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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