Hand-Schiiller-Christians Disease

Osvath P, Kovacs K, Lerhner J, Godo B (1970) Development of atopic allergy to synthetic lysine vasopressin in a child suffering from Hand-Schiiller-Christian disease. Allerg Asthma 16 97-101... 

Tumors of the anterior lobe of the hypophysis and the midbrain are responsible for the development of 30-40% of the cases of diabetes insipidus. Chronic encephalitis causes diabetes insipidus in 8-15% of the cases, but in more than 20% of the cases the anatomical reasons for the development of diabetes insipidus are not known. In an idiopathic, hereditary form of diabetes insipidus, no anatomical changes can be recognized. Occasionally, Hand-Schiiller-Christian disease is responsible for the development of diabetes insipidus. 

Studies with normal children (Sharma and Sur, 1967) showed that serum sialic acid levels were independent of age and sex. In children with various diseases—tubercular meningitis, rickets, and Hand-Schiiller-Christian disease—the serum sialic acid levels increase. 

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