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Hammond postulate tetrahedral intermediate

The tetrahedral intermediate is a high-energy intermediate. Therefore, independently of its charge and also independently of the detailed formation mechanism, it is formed via a late transition state. It also reacts further via an early transition state. Both properties follow from the Hammond postulate. Whether the transition state of the formation of the tetrahedral intermediate has a higher or a lower energy than the transition state of the subsequent reaction of the tetrahedral intermediate determines whether this intermediate is formed in an irreversible or in a reversible reaction, respectively. Yet, in any case, the tetrahedral intermediate is a transition state model of the rate-determining step of the vast majority of SN reactions at the carboxyl carbon. In the following sections, we will support this statement by formal kinetic analyses of the most important substitution mechanisms. [Pg.262]


See other pages where Hammond postulate tetrahedral intermediate is mentioned: [Pg.7]    [Pg.272]    [Pg.290]    [Pg.413]    [Pg.234]    [Pg.315]    [Pg.1004]    [Pg.1001]   
See also in sourсe #XX -- [ Pg.224 , Pg.234 ]




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