Tacrine Haloperidol

Drugs that may be affected by SSRIs Drugs that may be affected by SSRIs include alcohol, benzodiazepines, beta blockers, buspirone, carbamazepine, cisapride, clozapine, cyclosporine, diltiazem, digoxin, haloperidol, hydantoins, lithium, methadone, mexiletine, nonsedating antihistamines, NSAIDs, olanzapine, phenothiazines, phenytoin, pimozide, procyclidine, ritonavir, ropivacaine, sumatriptan, sulfonylureas, sympathomimetics, tacrine, theophylline, tolbutamide, tricyclic antidepressants, and warfarin. 

Dysken MW, Mendels J, LeWitt P Milacemide a placebo-controlled study in senile dementia of the Alzheimer type. J Am Geriatr Soc 40 503-506, 1992 Dysken MW, Johnson SB, Holden L, et al Haloperidol concentrations in patients with Alzheimer s Disease. Am J Geriatr Psychiatry 2 124-133, 1994 Eagger SA, Levy R, Sahakian BJ Tacrine in Alzheimer s disease. Lancet 337 989-929, 1991... 

CYP1A2 Antidepressants amitriptyline, clomipramine, imipramine, fluvoxamine Neuroleptics haloperidol, phenothiazines, thiothixene, clozapine, olanzapine Others tacrine, caffeine, theophylline, acetaminophen, phenacetin No report of polymorphism until 1999 significance of following findings remains unclear 1C reduced activity 23% in Japanese 1F higher inducibility 32% in Caucasians... 

McSwain ML, Forman LM. Severe parkinsonian s3miptom development on combination treatment with tacrine and haloperidol. J Clin Psychophannacol (1995) 15, 284. 

An isolated report describes an 87-year-old man with dementia, who started taking haloperidol 5 mg daily for symptoms of agitation and paranoia. Doses of greater than 5 mg were noted to cause extrapyramidal symptoms. After 10 days, tacrine 10 mg four times daily was added. Within 72 hours he developed severe parkinsonian symptoms, which resolved within... 

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