Haloperidol Sodium valproate

A 30-year-old man with bipolar affective disorder was given intravenous sodium valproate 20 mg/kg/day without any major problem. Later, he was given oral haloperidol 10 mg bd for persistent aggressive behavior and manic symptoms. The next day he developed a sense of imbalance and started swaying. He was drowsy and had cerebellar ataxia. Haloperidol was withdrawn and within 1 day his ataxia had disappeared completely in spite of continuing valproate. 

Sekhar S, Kaha B, Mendhekar DN, Tekur U. Efficacy of sodium valproate and haloperidol in the management of acute mania a randomized open-label comparative study. J Chn Pharmacol 2010 50(6) 688-92. 

SODIUM PHENYLBUTYRATE CORTICOSTEROIDS, HALOPERIDOL, VALPROATE Possibly i efficacy of sodium phenylbutyrate These drugs are associated with t ammonia levels Avoid co-administration... 

---