Halocynthiaxanthin

Nishino, H., Tsushima, M., Matsuno, T., Tanaka, Y., Okuzmi, J., Murakoshi, M., Satomi, Y., Takayasu, J., Tokuda, H., Nishino, A., and Iwashima, A. 1992. Anti-neoplastic effect of halocynthiaxanthin, ametabolite of fucoxanthin. Anticancer Drugs, 3, 493 197. 

Terpene hydroquinones which are well known as constituents of other marine organisms have been isolated from the ascidian Aplidium constellatum, (750). These compounds demonstrated activity as anticancer agents. In the case of A. constellatum, 2-methyl-2-(4-methylpent-3-enyl)-2/f-chromen-6-ol could be identified. Five new carotenoids have been obtained from tunicates, halocynthiaxanthin (1067) (751) and mytiloxanthinone (1068) (752) from Halocynthia roretzi, sidnyax-anthin (1069) from Sidnyum argus (755) and amarouciaxanthin A (1070) and B (1071) from Amaroucium pliciferum (733a). Halocynthia aurantium furnished two known carotenoids, astaxanthin and diatoxan-... 

Matsuno, T., and M. Ookubo A New Carotenoid, Halocynthiaxanthin from the Sea Squirt, Halocynthia roretzi. Tetrahedron Lett. 22, 4659 (1981). 

K. (2006) Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells. Comp. Biochem. Physiol., 142C, 53-59. 

Matsrmo, T. and Ookubo, M. (1981) A new carotenoid, halocynthiaxanthin from the sea squirt, Halocynthia roretzi. 

Yamano, Y, Tode, C., and Ito, M. (1995) Carotenoids and related polyenes. Part 3. First total synthesis of fucoxanthin and halocynthiaxanthin using oxometallic catalyst. J, Chem, Soc, Perkin Trans. 1,1895-1904. 

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