Halichondria moorei

A Japanese species of Epipolasis contained five sterol sulfates named halistanol sulfates A-E (536-540), which differ from the original halistanol sulfate (532) from Halichondria moorei [449]. Structures were elucidated by spectroscopic and chemical techniques. Halistanol sulfates F-H (541-543) are three additional sterol sulfates from Pseudaxinyssa digitata that inhibit HIV in vitro [450]. 

Gregson. R.P. et al. Fluorine is a Major Constituent of the Marine Sponge Halichondria moorei," Science 206. 1108-1109 (1979). 

Halistanol sulfate (532) from Halichondria cf. moorei is a tris-sodium sulfate salt, which possesses antimicrobial, hemolytic, and ichthyotoxic activity [444]. It was later isolated from two sponges of the genus Topsentia as the free sterol and found to inhibit pp60v-src protein tyrosine kinase activity [445]. The tris(2-aminoimidazolium) salt of halistanol sulfate (533) was isolated from Topsentia sp. from Japan and is also antimicrobial [446]. 

Fusetani, N., Matsunaga, S., and Konosu, S., Halistanol sulfate an antimicrobial steroid sulfate from Halichondria cf. moorei Bergquist, Tetrahedron Lett., 22, 1985, 1981. 

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