Haldane effect

Deoxygenated It is important to plot this line. At any Paco2, the C02 content will be higher than that of oxy-Hb. This is a graphical representation of the Haldane effect. As a result, the curve is plotted slightly above that of oxy-Hb. Be sure to point this relationship out to the examiner. 

Haldane effect brain and heart, which are esp 02-dependent for metabolism, are most severely affected... 

Transport of CO2 is coupled to O2 through the Bohr effect (effect of CO2 tension on the blood O2 content) and the Haldane effect (effect of PO2 on the blood CO2 content). Diffusion of CO2 is faster than that of O2 because CO2 solubility in tissue is higher theoretical studies predict that countercurrent exchange of CO2 between arterioles and venules is of major importance so that equilibration of CO2 tension with surrounding tissue should occur before capillaries are reached. Experiments are needed to test these theoretical predictions. 

Bohr and Haldane effects. Terminology. Henderson s interpretation of oxygen Bohr effect. Indirect estimates of titration curve of oxyhemoglobin. Direct differential titration of hemoglobin and oxyhemoglobin. Reversed Bohr effect at acid reactions. The existence of two oxygen-... 

H+], calculation of, 192, see also Hydrogen ion Haber, Fritz, 151 Haber process, 140, 150 Hafnium, oxidation number, 414 Haldane, J. B. S., 436 Half-cell potentials effect of concentration, 213 measuring, 210 standard, 210 table of, 211, 452 Half-cell reactions, 201 Half-life, 416 Half-reaction, 201 balancing, 218 potentials, 452 Halides... 

The lethal effects of carbon monoxide on hemoglobin had been analyzed by Claude Bernard and shown to be due to the formation of an iron-carbonyl compound. In 1891 Mond and Langer showed that iron pentacarbonyl could be dissociated by light, and in 1897 J.S. Haldane and J.L. Smith found light would decompose the carbonyl compound of hemoglobin. Other metal carbonyls are not photodecomposed. 

Excluded volume effects in cytoplasm, MOLECULAR CROWDING Excluding kinetic reaction mechanisms, HALDANE RELATION EXERGONIC EXOCYTOSIS EXOENZYME EXOERGIC Exo-j8-f ru ctosi d ase,... 

MICROTUBULE ASSEMBLY KINETICS KINETIC ELECTROLYTE EFFECT IONIC STRENGTH KINETIC EQUIVALENCE KINETIC AMBIGUITY KINETIC HALDANE RELATIONSHIPS HALDANE RELATIONSHIPS... 

Hay-Roe, M.M., Lamas, G. and Nation, J.L. (2007). Pre- and post-zygotic isolation and Haldane mle effects in reciprocal crosses of Danaus erippus and Danaus plexippus (Lepidoptera Danainae), supported by differentiation of cuticular hydrocarbons, establish their status as separate species. Biol. J. Linn. Soc., 91,445 453. 

Faraci and Walsh263 studied the substrate and solvent deuterium isotope effects of the reactions catalyzed by alanine racemases of S. typhimurium (DadB and Air enzymes) and B. stearothermophilus. Although the kinetic constants for all three alanine racemases obey the Haldane equation, i.e., Keq= 1 (this confirms that the enzymes are true racemases), the individual Micaelis-Menten parameters in both directions show marked difference in the binding of each isomer. This suggests a structural asymmetry at the active sites of these enzymes. The asymmetry in the recognition and turnover of substrate enantiomer was also clearly seen in the results of isotope effect experiment with DadB enzyme. In the d-... 

The French physiologist Claude Bernard (1857) and the British physiologist Haldane (1895a) inferred that the toxicity of CO was caused by its interaction with hemoglobin. In his review of carbon monoxide, Lilienthal (1950) writes It has been said many times that the effect of CO on man may be attributed to two actions and, in essence, to these two actions alone (a) occupation of the Hb molecule by CO, with a resultant decrease in the O2 transport capacity of the blood and (b) alteration of 02Hb dissociation... 

FIGURE 20.2. Effect of carboxyhemoglobin (COHb) upon the shape of the oxyhemoglobin dissociation curve in healthy males. Based on data of Haldane and Priestley (1935) as presented by Shephard (1983). 

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