Hairpin-Caged MO

The DMNB hairpin cMOs have been applied to the knockdown of several genes, including no tail a ntla), heart of glass (heg), floating head iflh), and ETSl-related protein (etv2) [5, 6]. They also helped reveal an important regulatory mechanism in embryo development, as discussed in Section 23.4. [Pg.342]

Apart from UV-cleavable DMNB linkers, a bromohydroxyquinoline (BHQ) linker was also introduced into hairpin cMOs, which enables two-photon activation of MO function at 750 nm [6]. This BHQ linker can provide improved spatial resolution and is less likely to cause any phototoxicity because of UV exposure. [Pg.342]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...