Haematopoietic stem cell transplantation HSCT

The final chapter comprises two reports on clinical haematopoietic stem cell transplantation (HSCT). Viktor Khomenko shares the experience of the Kiev center for stem cell transplantation. The final article in this book by Axel Zander and colleagues summarises data with the use of Antithymocyte globuline (ATG) in (HLA-mismatched) allogeneic transplantation, an approach which was promoted in the Hamburg Clinic for HSCT. 

Donnelly, J.P. Mouton, J.W. Blijlevens, N.M.A. Smiets, A. Verweij, P.E. Depauw, B.E. Pharmacokinetics of a 14 day course of itraconazole nanocrystals given intravenously to allogenic haematopoietic stem cell transplant (HSCT) recipients. Abstr. Intersci. Conf Antimicrob. Agents Che-mother. 2001, 41, 5. 

The drug interaction between oral voriconazole 400 mg and a stable dose of oral ciclosporin A (CsA) was compared in a prospective trial of 20 adult recipients of haematopoietic stem cell transplantation (HSCT). With concurrent therapy, the median concentration/dose (C/D) ratio of CsA increased significantly from 64.1 to 114.3(ng/mL)/(mg/kg) (p<0.01) [4 ]. 

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