HA Receptors - Cellular Hyaladherins

Due to this significant importance, there were many attempts to influence HA-protein interactions firstly, the overexpression of soluble hyaladherins that may displace HA completely from its endogeneous cell surface receptors [121]. Secondly, the administration of defined HA oligosaccharides that 

RHAMM is a HA receptor that can be present either on the cell surface, in the cytoplasm or even in the nucleus. Interactions between RHAMM and HA may trigger a lot of cellular signaling pathways, including those that involve protein kinase C, MAP kinases, phosphatidylinositol and tyrosine kinases [125]. Several recent studies have clearly demonstrated the involvement of RHAMM in the locomotion of TGF-)9-stimulated fibroblasts, smooth muscle cells, macrophages as well as Ras-transformed fibroblasts [126], i.e. the processes that are most likely important in the development of cancer. 

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