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H K-ATPase Inhibitors Esomeprazole Nexium

USAN Omeprazole Trade Name. Prilosec AstraZeneca Launched 1985 M.W. 345 21 [Pg.21]

Esomeprazole Trade Name Nexium AstraZeneca Launched 2001 M.W. 713.13 [Pg.21]

Esomeprazole (2) is the (5)-enantiomer of racemic omeprazole (1). The former has better pharmacokinetics and pharmacodynamics than the latter and therefore possesses higher efficacy in controlling acid secretion and has a more ideal therapeutic profile. [Pg.23]

One prominent example is AstraZeneca s H /K -ATPase inhibitor, pyridine-containing omeprazole (Prilosec) and its enantiomerically pure follow-up esomeprazole (Nexium). [Pg.13]

Omeprazole (Prilosec, 21), the first H /K -ATPase inhibitor, also known as a proton pump inhibitor (PPI), was marketed as a treatment for gastric ulcers since 1988. It functions by preventing acid production in the mucosa. Omeprazole was the best-selling drug for several years until its patent expiration in 2001, at which time, esomeprazole (Nexium, 22), tihe (S)-enantiomer of racemic omeprazole (21), was launched. The mechanism of... [Pg.403]

See other pages where H K-ATPase Inhibitors Esomeprazole Nexium is mentioned: [Pg.21]    [Pg.21]    [Pg.23]    [Pg.25]    [Pg.27]    [Pg.22]    [Pg.21]    [Pg.21]    [Pg.23]    [Pg.25]    [Pg.27]    [Pg.22]    [Pg.380]    [Pg.541]    [Pg.613]    [Pg.621]   


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ATPase inhibitor

ATPases inhibitors

Esomeprazol

H * -ATPase

H, K-ATPase

H, K-ATPase inhibitors

K , inhibitors

K+-ATPase

Nexium

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