Gyrus dentatus

In brains without AD, mRNA NGF is detected in granular cells of the gyrus dentatus and in pyramidal CA cells, as well as in diverse cortical neurons and glial cells. The cholinergic neurons of the basal ganglia not only re-... 

Figure 3. Distribution of histamine-immunoreactive nerve fibers in normal human hippocampal structures. F, fimbriae CA1-CA3, cornu ammonis, areas 1-3 GD, gyrus dentatus S, subilucum PHG, parahippocampal gyrus. From Panula et al.42...

Neuronal expression of GLAST protein has not been detected anywhere in the nervous system in vivo, neither in the adult nor during development, although a possible expression of GLAST mRNA in granule cells of the mouse hippocampus (gyrus dentatus) at birth (PO) has been described (Sutherland et al., 1996), but this has not been verified with antibodies. However, it has recently been reported that GLAST protein is transiently expressed in a subpopulation of cultured embryonic hippocampal neurons (Plachez et ah, 2000). 

Post-mortem examination was done in four of the 10 patients (Patient Nos. 5, 7-9). Brain Al contents of cerebral cortex of these four patients were 0.93 to 1.81 pg/g dry weight (normal 0.14-0.22 pg/g values in patients with chronic Al encephalopathy 0.4-3 pg/g) [65]. On light-microscopic evaluation of the gyrus frontalis superior and inferior, hippocampus, nucleus lentiformis and insula, capsula interna and caudatus, thalamus, nucleus dentatus cerebelli, brainstem, and pons, non-specific changes of some fibrohyalin thickening of the wall of the blood vessels and brain edema were noted. 

---