Guidelines Official Analytical Chemists

Association of Official Analytical Chemists (AOAC) International (2000), Method validation programs (OMA/PVM Department), including Appendix D Guidelines for collaborative study procedures to validate characteristics of a method of analysis, available http //www.aoac.org/vmeth/devmethno.htm. 

The main purpose of this paper is to explore the robustness of SFE as an analytical technique. To do this, we have used guidelines published by the AOAC (14), Association of Official Analytical Chemists, as a way to define and measure contributors to method robustness. In particular, method robustness can be characterized by the reliability of the analytical instrumentation employed and the precision (variability) of the results. In the "Results and Discussion" section, anecdotal information will be presented as an indication of instrumentation reliability and many studies will be summarized to provide precision data for the factors of replicability, repeatability, and reproducibility. 

Guidelines for Collaboration between the Association of Official Analytical Chemists (AOAC) and the Collaborative International Pesticide Analytical Council (CIPAC)", J. Assoc. Off. Anal. Chem.. 1974, 447-9. 

As an analytical approach to residue analysis, immunoassay methods are not well characterized, and no validation protocols have been established. The Association of Official Analytical Chemists, whose primary purpose is validation of analytical methods, established a Task Force on Test Kits and Proprietary Methods (2), which has addressed some of the issues relating to immunoassay methods. The International Union of Pure and Applied Chemistry s Commission on Food Chemistry has established a Working Group on Immunochemical Methods, whose first project is to develop draft guidelines on criteria for evaluation, validation, and quality control for r o-immunoassay methods (10). Similar guidelines for EIAs will also be developed. These documents will assist in development and standardization of requirements for precision for both between-laboratories and within-laboratory andyses, accuracy, and ruggedness, and— for qualitative methods— false positive and false negative rates. 

AOAC International (Association of Official Analytical Chemists International) (2002), Guidelines for Single Laboratory Validation of Chemical Methods for Dietary Supplements and Botan-icals [available at http //www.aoac.org/dietsupp6/Dietary-Supplement-web-site/ValidProc.html]. 

---