Guidelines for the Conduct of Drug Studies in Pregnant Women

Guidelines for the Conduct of Drug Studies in Pregnant Women 

FIGURE 22.6 Paired comparisons of measured ratios of caffeine metabolites to parent drug in nonpregnant (solid bars) and pregnant (open bars) women. Comparisons were made of the metabolic activities of CYP1A2, xantlaine oxidase (XO), W-acetyl transferase (NAX), and CYP3A4 = P 0.05, = P 0.005). (Data from Bologa M 

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