Guanosine supramolecular assembly

Several natural and synthetic helical macromolecules such as DNA, polypeptides, and polyisocyanates form, in the appropriate solvent, cholesteric meso-phases. Also self-assembled supramolecular systems formed by guanosine derivatives 2 and 3 (G-wires), which are essentially four-stranded helices (Figure 7.8), behave in a similar way.35... 

Davis JT, Spada GP (2007) Supramolecular architectures generated by self-assembly of guanosine derivatives. Chem Soc Rev 36 296-313... 

On the other hand, the G-quadruplex with a twisted supra molecular architecture represents a nice example of a dynamic chiral supramolecular system, when guanine and guanosine molecules are used. Molecular chirality may be used as a tool to assemble molecules and macromolecules into supramolecular structures with dissymmetric shapes. The supramolecular chirality, which results from both the properties and the way in which the molecular components associate, is by constitution dynamic and therefore examples of large-scale transcription of such virtual chirality remain rare. 

Supramolecular architectures generated by self-assembly of guanosine derivatives 07CSR296. 

Formation of a strong complex between 2,7-diamldo-l,8-naphthyridine (DAN) and urea derivative of guanosine (UG). (Reprinted with permission from Park, T., and Zimmerman, S. C. 2006. Formation of a miscible supramolecular polymer blend through self-assembly mediated by a quadruply hydrogen-bonded heterocomplex. /. Am. Chem. Soc. 128 11582-11590. Copyright 2006, American Chemical Society, USA.)... 

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