Guanine nucleotide regulatory

Lefkowitz, RJ, Cotecchia, S, Samama, P and Costa, T (1993) Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. TIPS 14 303-307. 

Dohlman H, Caron M, Stader C, Am-laiky N, Lefkowitz R. A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry 1988 27 1813-1817. 

Anand-Srivstava MB. 1992. Enhanced expression of inhibitory guanine nucleotide regulatory proteins (Gia) in spontaneously hypertensive rats relationship to adenylate cyclase inhibition. Biochem J 288 79-85. 

Anand-Srivastava MB. 1993. Rat platelets from spontaneously hypertensive rats exhibit decreased expression of inhibitory guanine nucleotide regulatory protein relationship with adenylate cyclase activity. Circ Res 173 1032-1039. 

Clark CJ, Milligan G, Connell JM. 1993.Guanine nucleotide regulatory protein alterations in the Milan hypertensive rat strain. J Hypertens 11 1161-1169. 

Susani EE, Manders WT, Knight DR, Vatner DE, Vatner SF, Homey CJ. 1989. One hour of myocardial ischemia decreases the activity of the stimulatory guanine-nucleotide regulatory protein Gs. Circ Res 65 1145-1150. 

Anand-Srivastava, M.B. 1989. Angiotensin II receptors negatively coupled to adenylate cyclase in rat myocardial sarcolemma. Involvement of inhibitory guanine nucleotide regulatory protein. Biochem. Pharmacol. 38 489-496. 

Bushfield, M., S.L. Griffiths, G.J. Murphy, N.J. Pyne, J.T. Knowler, G. Milligan, P.J. Parker, S. Mollner, and M.D. Houslay. 1990. Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepa-tocytes. Biochem. J. 271 365-372. 

Strassheim, D., T. Palmer, and M.D. Houslay. 1991. Genetically acquired diabetes adipocyte guanine nucleotide regulatory protein expression and adenylate cyclase regulation. Biochim. Bio-phys. Acta 1096 121-126. 

Insulin and its action on guanine nucleotide regulatory proteins... 

Many hormones, which bind to cell surface receptors, stimulate their effector systems to generate an intracellular second message by interacting with specific guanine nucleotide regulatory proteins (G-proteins) [85-89]. 

Other evidence for the involvement of a G-protein in the action of insulin has come from studies by Walaas and co-workers [104]. They have demonstrated that insulin stimulated the activity of a cyclic AMP-dependent protein kinase activity in sarcolemma membranes. As this effect of insulin was enhanced if micromolar concentrations of GTP-binding protein were present, they suggested that a guanine nucleotide regulatory protein was involved in the hormonal control of this kinase. Indeed, cholera toxin also appeared to obliterate this action of insulin, as it did the effect of insulin on liver adenylate cyclase and the peripheral plasma membrane cyclic AMP phosphodiesterase in liver. 

Verghese, M. W., Smith, C. D., and Snyderman, R. (1986). Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants. J. Cell Biochem. 32, 59-69. 

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