Growth rate effects

The number of cells within each colony depends on the number of cell doublings and can be used as an estimate of the effects, if any, of the drug on the cell doubling time. A clonogenic assay can thus discriminate between cytotoxic (cell kill) and cytostatic (decreased growth rate) effects. Because a cytostatic effect may be lost upon removal of the drug a cytotoxicity assay based on colony formation is also described since this allows continuous drug exposure. 

Bidigare R.R., Fluegge A., Freeman K.H., Hanson K.L., Hayes J.M. 10 others (1997) Consistent fractionation of 13C in nature and in the laboratory growth-rate effects in some haptophyte algae. Gloh. Biogeochem. Cycles 11,279—92. 

L. L., Laws, E.A., Milder, J., Millero, F.J., Pancost, R., Popp, B.N., Steinberg, P.A., Wakeham, S.G, 1997. Consistent fractionation of C in nature and in the laboratory Growth rate effects in some haptophyte algae. Global Biogeochem Cycles 11 279-292. 

Seed germination, plant growth rate, effect on m acro-organisms, "heavy" metal accumulation in plants... 

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