Growth, crowding factor

Boltzmann constant corrective growth crowding factor coordination number for an aggregate particle mass-transfer coefficient... 

Leukemic cells have growth and/or survival advantages over normal cells, leading to a crowding out phenomenon in the bone marrow. This growth advantage is not caused by more rapid proliferation as compared with normal cells. Some studies suggest that it is caused by factors produced by leukemic cells that either inhibit normal cellular proliferation and differentiation, or reduce apoptosis as compared with normal blood cells. 

Density-dependent inhibition is a term describing the phenomenon in which crowded cells stop dividing (Campbell et al., 1999). When cells divide to the point that they touch each other and fill the available space, they automatically stop dividing. When cells die and cause a hole to form, adjacent cells begin to divide until they again fill the space. This occurrence is apparently due to inadequate amounts of nutrients and growth factors when the cells are crowded (Campbell et al., 1999). 

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