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Growth Conditions and Potency

Mammal-derived TEFs underestimate the potency of planar PCB mixtures in fish. TEE values of non-ortho PCB congeners based on mortality of rainbow trout in early life stages are as much as 1000 times lower than TEFs proposed for human risk assessment. TEFs for PCBs were compared using cytochrome P4501A1 induction measured as EROD activity in a rainbow trout liver cell line and in a rat hepatoma cell line. EROD activity in trout liver cells was induced only by PCBs 77, 81, 118, and 126 under normal growth conditions, and in some cultures with PCBs 105,156, and 169. The trout TEFs were 0.023 for PCB 126, 0.064 for PCB 81,0.0034 for PCB 77,0.00016 for PCB 169, and 0.000017 for PCB 118 TEFs for PCBs 105 and 156 were <0.00003. In rat cells, however, all seven PCBs clearly induced EROD activity. It was concluded that the toxic impact of PCBs on rainbow trout is overestimated by risk assessment TEFs based on... [Pg.614]

Marijuana Chemistry explains the psychoactive constituents of cannabis, and the effect of growth conditions, harvesting and processing, and method of ingestion on potency. This new edition of the widely respected classic features 64 pages of updates based on current research and black market studies. [Pg.200]


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Growth conditions

Potency

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