Growth arrest, temporary

Temporary Growth-Arrest as a Defense Against Oxidative Stress. 67... 

Increased Growth HA Temporary Growth Arrest flA Pennanent Growth Arrest... 

Very important early studies on transient adaptation to oxidative stress were performed by Spitz et al. [24] and by Laval [25]. After 4-6 h of temporary growth-arrest many cells exposed to 120-150 pM hydrogen peroxide, or 2-5 pmol 10 cells, undergo further changes that can be characterized as transient adaptation to oxidative stress (Scheme 2). In the mammalian fibroblasts we [15, 22, 23, 26-31] and others [24,25] have studied, maximal adaptation is seen approximately 18 h after initial exposure to hydrogen peroxide i.e., some 12-14 h after they exit from temporary growth-arrest. In bacteria such as E. Coli and salmonella maximal adaptation is seen 20-30 min after oxidant exposure [16,17,26], whereas yeast cells require some 45 min for maximal adaptation [18,26]. 

If dividing mammalian cells are exposed to higher concentrations of H2O2 than those that cause temporary growth-arrest and transient adaptation, they can be forced into a permanently growth-arrested state (Scheme 2). Thus, cells exposed to H2O2 concentrations of 250-400 pM,or 9-14 pmol 10 cells, will never divide again [15]. 

Laborit, H., de Bmx, J., and Thuret, F., Temporary arrest of ascitic cancer growth in mice by intraperitoneal injection of liver mitochondrial suspension, Hgreiio/ogie, 12, 325, 1971. 

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