Group methodology

By suitable modification of reaction conditions, it was found possible to reduce 859 to keto alcohol 873 K The subsequent conversion of this intermediate to 874 proceeded without event. However, 874 could not be oxidized to aldehyde 875. Overoxidation to produce 876 or 877 (Jones conditions) invariably was observed due to the extreme sensitivity of874. This potentially expedient route to dodecahedrane therefore had to be abandoned and recourse made to blocking group methodology. 

Y. Shai, L. Kirk, M.A. Channing, B.B. Dunn, M.A. Lesniak, R.C. Eastman, R.D. Finn, J. Roth, K.A. Jacobson, F-labeled insulin A prosthetic group methodology for incorporation of a positron emitter into peptides and proteins, Biochem. 28 (1989) 4801 806. 

For the synthesis of oligosaccharide units containing residues of configurationally accessible 6-deoxyhexoses, standard protecting-groups methodology has... 

A powerful example of the utility of the Pale group methodology can be found in their selective coupling of molecules bearing a number of reactive alkynes. By careful selection of conditions, they selectively coupled each alkyne of a trialkyne, bearing one TMS group and one TIPS group, to vinyl triflates or aryl iodide (Scheme 1.69).146 147... 

Almost two-thirds of the reported uses of the chiral methyl group methodology fall into this category. The chiral methyl group may be formed from either... 

In situations where the third hydrogen required to convert a methylene into a methyl group comes from the same substrate, it is possible to determine by the chiral methyl group methodology whether this hydrogen is transferred inter-... 

A Children s executive explained, "We wanted to understand directly from clinicians and families whether this was a safe place to give and receive care, based on their experience and to learn what they perceived to be barriers in patient safety. The goal was to gain a portrait of the actual safety experience within the organization as a starting point to understand the culture. The focus group methodology was used to create a locally relevant view of safety rather than extrapolate from published studies."... 

S. Caplan, "Using focus group methodology for ergonomic design," Ergonomics, 33(5) 527-533,... 

Scheme 12 Synthesis of trimesitylsilylium borate, 28[B(C5F5)4], using the allyl leaving group methodology [17, 19]...

A review of chiral methyl group methodology includes various terpenoid examples 7... 

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