Grignard reagents organic synthesis

A5. R. C. Fuson, Advanced Organic Chemistry. Wiley, New York, 1950. See Chapter VII (pp. 154—176) on the uses of organometallic compounds (mainly Grignard reagents) in synthesis. 

An ability to form carbon-carbon bonds is fundamental to organic synthesis The addition of Grignard reagents to aldehydes and ketones is one of the most frequently used reactions m synthetic organic chemistry Not only does it permit the extension of carbon chains but because the product is an alcohol a wide variety of subsequent func tional group transformations is possible... 

Alcohol synthesis via the reaction of Grignard reagents with carbonyl com pounds (Section 14 6) This is one of the most useful reactions in synthetic organ ic chemistry Grignard reagents react with formaldehyde to yield primary alco hols with aldehydes to give secondary alcohols and with ketones to form terti ary alcohols... 

Yasuda S, Yorimitsu H, Oshima K (2008) Synthesis of aryliron complexes by palladium-catalyzed transmetalation between [CpFe(CO)2l] and aryl Grignard reagents and their chemistry directed toward organic synthesis. Organometallics 27 4025 027 Jonas K, Schieferstein L (1979) Simple route to Li- or Zn-metalated r -cyclopentadien-yliron-olefin complexes. Angew Chem Int Ed Engl 18 549-550... 

Grignard reagents have great use in organic synthesis. 

TMC ATRA reactions can also be conducted intramolecularly when alkyl halide and alkene functionalities are part of the same molecule. Intramolecular TMC ATRA or atom transfer radical cyclization (ATRC) is a very attractive synthetic tool because it enables the synthesis of functionalized ring systems that can be used as starting materials for the preparation of complex organic molecules [10,11], Furthermore, halide functionality in the resulting product can be very beneficial because it can be easily reduced, eliminated, displaced, converted to a Grignard reagent, or if desired serve as a further radical precursor. The use of copper-mediated ATRC in organic synthesis has been reviewed recently and some illustrative examples are shown in Scheme 3 [10,11,31,32,33],... 

---