Grignard Crosscoupling

Scheme 10.87 Grignard crosscoupling of 1 -phenylethylmagnesium chloride and vinyl bromide with sulfide ligands.

Scheme 10.89 Arenethiolatocopper(I)-catalysed Grignard crosscouplings of allylic substrate.

Scheme 10.90 Cu-catalysed Grignard crosscouplings of allylic substrates with fer-rocenylthiolate ligands.

ASYMMETRIC GRIGNARD CROSSCOUPLING Ferrocenylphosphincs. ASYMMETRIC HYDROBORATION Dilongifolylborane. ( + )-Di-3-pinanylborane. Monoisocamphenylboranc. Thexylborane. 

Hayashi, T., Konishi, M., Ito, H., Kumada, M. Optically active aiiyisiianes. 1. Preparation by palladium-catalyzed asymmetric Grignard crosscoupling and anti stereochemistry in electrophilic substitution reactions. J. Am. Chem. Soc. 1982,104,4962-4963. 

The compound (/ ,pS)-10 and its enantiomer have been used for asymmetric Grignard crosscoupling reactions with nickel and palladium (Section D.1.1.3.), and for hydrosilylation reactions using palladium (Sections D.4.3. and D.9.). 

Kamikawa T, Hayashi T (1997) Control of reactive site in palladium-catalyzed Grignard crosscoupling of arenes containing both bromide and triflate. Tetrahedron Lett 38 7087-7090... 

Scheme 4.4 Mechanism of the nickel-phosphine catalyzed asymmetric Grignard crosscoupling [78]...

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