Green Chemistry Institute Pharmaceutical Roundtable

ACS Green Chemistry Institute Pharmaceutical Roundtable (20007) Lessons learned through measuring green chemistry performance - the pharmaceutical experience, presentation on website http //portal. acs. org/portal/ fileFetch/C/CTP 005585/pdf/ CTPH)05585. pdf (last accessed 15 October 2008). 

Figure 15.6 Example output of the process mass intensity and life cycle assessment tool developed by the American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable. The data presented in the columns provide the metrics for steps 1,2, 3, and the total of the synthesis. Some of the instructions in the tool are included as an illustration.

The key reactions used within medicinal and process chemistry for the pharmaceutical industry are well documented and the key sustainability challenges have previously been described, for example by the ACS Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR). For the purposes of the IMI call, the EFPIA members focussed on the following areas of outstanding need ... 

ACS CGI (2010) ACS GCI Pharmaceutical Roundtable 2010 Year in Review. American Chemical Society Green Chemistry Institute. Washington, DC, http //portal.acs.org/portal/ PublicWeb Site / greenchemistry/ industriainnovation / roundtable/ CNBP 026603 (last accessed October 23,... 

The Green Chemistry Institute (GCl) Pharmaceutical Roundtable has used the Process Mass Intensity (PMl) [12], defined as the total mass used in a process divided by the mass of product (i.e. PMl = E factor -i- 1) to benchmark the environmental acceptability of processes used by its members (see the GCl website). The latter include several leading pharmaceutical companies (Eh Lilly, GlaxoSmithKline, Pfizer, Merck, AstraZeneca, Schering-Plow, and Johnson Johnson). The aim was to use this data to drive the greening of the pharmaceutical industry. We believe, however, that the E factor is to be preferred over the PMl since the ideal E factor of 0 is a better reflection of the goal of zero waste. 

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