Green Chemical Synthesis and Click Reactions

Maria Jos Arevalo, Oscar Lopez, and Maria Victoria Gil 

Click chemistry has recently aroused great interest and emerged as one of the most powerful tools in drug discovery and chemical biology [2]. 

Among the different procedures that can be considered as click chemistry reactions, cycloadditions, and particularly the Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (CuAAc) between azides and terminal alkynes to form 1,2,3-triazoles, are the most widely used. This reaction has found applications across many diverse research areas. In the following sections, the potential of this click reaction and its applications are reviewed. 

The cycloaddition, in most cases, is carried out at room temperature in aqueous media and is compatible with an ample number of functional groups present in the molecules. Since its discovery, it has become one of the most applied organic reactions in this century in many areas of research. 

CUckReactions in Organic Synthesis, First Edition. Edited by Srinivasan Chandrasekaran. 

---

I 3 Green Chemical Synthesis and Click Reactions 3.2.1.3 Metalated Reagents as Catalysts... 

---