Graphing and Reporting Concentration-Response Data

Graphing and fitting of the inhibtor concentration-response data to obtain the IC50 is typically the primary mechanism for assessing the relative potency of lead compounds and lead compound analogues (see below). The IC50 can be determined by 

Compound Identification Number IC50 (pM) Standard Error (SE) of Fit or Standard Deviation (SD) from Multiple, Independent Determinations Hill Coefficient Maximum % Inhibition Attained Comments 

00 (SE) 0.46 98 Plotted data looked biphasic maybe two unresolved IC50S 

Note The data columns provide the minimum information required to assess the relative potency of the compounds and the quality of the experimental data used to generate the IC50 value. 

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